Guest Editorial: General considerations for integrating pharmacogenomics into the mainstream medical practice
George Patrinos, Department of Pharmacy, School of Health Sciences, University of Patras
Research: Endothelial nitric oxide synthase gene polymorphisms -786T>C and 894G>T in coronary artery bypass graft surgery patients
Georgia Ragia, Anna Tavridou, Kostas I Arvanitidis, Vangelis G. Manolopoulos, Laboratory of Pharmacology, Medical School, Democritus University of Thrace, Eleftherios Nikolaidis, George Bougioukas, Cardiothoracic Surgery Clinic, Academic General Hospital of Alexandroupolis, Alexandroupolis, Stavroula Kanoni, George V. Dedoussis, Department of Science in Dietetics and Nutrition, Harokopio University
Research: Intronic polymorphisms of cytochromes P450
Magnus Ingelman-Sundberg and Sarah C. Sim, Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet
Research: An isolated case of lissencephaly caused by the insertion of a mitochondrial genome-derived DNA sequence into the 5’ untranslated region of the PAFAH1B1 (LIS1) gene
David S. Millar, David N. Cooper, School of Medicine, Cardiff University, Carolyn Tysoe, Royal Devon and Exeter NHS Foundation Trust, Lazarus P. Lazarou, Daniela T. Pilz, Rachel Butler, Institute of Medical Genetics, Cardiff and Vale University Health Board, University Hospital of Wales, Shehla Mohammed, Clinical Genetics Service, Guy’s Hospital, London, Katharine Anderson, Brighton General Hospital and Nadia Chuzhanova, Nottingham Trent University
Research: KinSNP Software for Homozygosity Mapping of Disease Genes using SNP Microarrays
El-Ad David Amir, Ofer Bartal, Department of Computer Science, Efrat Morad, Department of Life Sciences, Tal Nagar, Vered Chalifa-Caspi, National Institute of Biotechnology in the Negev, Jony Sheynin, Ruti Parvari, Department of Developmental Genetics and Virology, Ben-Gurion University of the Negev
Genome update: Evolutionary divergence and functions of the human acyl-CoA thioesterase gene (ACOT) family
Chad Brocker, Christopher Carpenter, Vasilis Vasiliou, Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Denver and Daniel W. Nebert, Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center
Software review: A survey of analysis software for Array-Comparative Genomic Hybridization Studies to Detect Copy Number Variation
Anis Karimpour-Fard, Lawrence E. Hunter, Center for Computational Pharmacology, University of Colorado School of Medicine, Laura Dumas, James M. Sikela, Department of Pharmacology, Neuroscience and Human Medical Genetics Programs, University of Colorado at Denver and Health Sciences Center, Tzulip Phang, Department of Medicine, University of Colorado Denver School of Medicine
Genome database: ArrayTrack, a FDA bioinformatics database tool
Joshua Xu, Reagan Kelly, Hong Fang, Z-Tech and Weida Tong, Center for Toxicoinformatics, Division of Systems Toxicology, National Center for Toxicological Research, US Food and Drug Administration
Book review: Color Atlas of Pharmacology
Maria Konstandi, University of Ioannina Medical School
Guest Editorial: Functional intronic polymorphisms: Buried treasure awaiting discovery within our genes
David N. Cooper, Institute of Medical Genetics, School of Medicine, Cardiff University
Research: Characterisation of a functional intronic polymorphism in the Human Growth Hormone (GH1) Gene
David S. Millar, Institute of Medical Genetics, School of Medicine, Cardiff University (et al)
Review: Gene-environment interaction tests for family studies with quantitative phenotypes: A review and extension to longitudinal measures
H. Moreno-Macias, Department of Environmental Health, Harvard School of Public Health (et al)
Review: The other lives of ribosomal proteins
R. B. Bhavsar, Department of Biology, University of Dayton (et al)
Genome Databases: ETHNOS: A versatile electronic tool for the development and curation of national genetic databases
George P. Patrinos, Department of Pharmacy, University of Patras (et al)
Update on gene completions and annotations: Human and mouse forkhead box (FOX) gene families
Daniel W. Nebert, Department of Environmental Health and Center for Environmental Genetics (CEG), University of Cincinnati Medical Center (et al)
Software Review: A survey of current software for network analysis in molecular biology
Sterling Thomas, Center for the Study of Biological Complexity and Danail Bonchev, Department of Mathematics and Applied Mathematics, Virginia Commonwealth University
Book Review: 'The Machinery of Life' by David S. Goodsell
Reviewed by Tina Toni, Division of Molecular Biosciences, Imperial College London
Guest Editorial: The clinical pharmacogeneticist: An emerging regulatory scientist at the US Food and Drug Administration
Issam Zineh, Associate Director for Genomics, Janet Woodcock, Center for Drug Evaluation and Research, US Food and Drug Administration
Review: The clinical application of UGT1A1 pharmacogenetic testing: gene-environment interactions
Sara Correia Marques, Faculty of Pharmacy, University of Lisbon and Ogechi N. Ikediobi, Department of Clinical Pharmacy, University of California San Francisco
Review: Hyperferritinemia-Cataract-Syndrome: Worldwide mutations and phenotype of an increasingly diagnosed genetic disorder
Gunda Millonig, Sebastian Mueller, Center for Alcohol Research and Salem Medical Center and Martina U. Muckenthaler, Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, University of Heidelberg
Review: From DNA to proteins via the ribosome: Structural insights into the working of the translation machinery
Xabier Agirrezabala, Structural Biology Unit, CIC-bioGUNE, Bizkaia Technology Park and Joachim Frank, Department of Biochemistry and Molecular Biophysics and Department of Biological Sciences, Columbia University
Genome Databases: The Human Cytochrome P450 (CYP) Allele Nomenclature website: A peer-reviewed database of CYP variants and their associated effects
Sarah C. Sim and Magnus Ingelman-Sundberg, Section of Pharmacogenetics, Karolinska Institutet
Update on gene completions and annotations: Krüppel-like factors: Three fingers in control
Shivalingappa K. Swamynathan, Department of Ophthalmology, University of Pittsburgh School of Medicine
Software Review: State of the art de novo assembly of human genomes from massively parallel sequencing data
Yingrui Li and Lars Bolund, Beijing Genomics Institute and Jun Wang, Department of Biology, University of Copenhagen
Book Review: ‘Metagenomics: Theory, Methods, and Applications’ edited by Diana Marco
Reviewed by Zissis C. Chroneos, University of Texas Health Sciences Center at Tyler
Guest Editorial: The Human Variome Project
Richard G. H. Cotton, Genomic Disorders Research Centre, Howard Florey Institute; Convenor, Human Variome Project
Research: Combination of 16S rRNA variable regions provide a detailed analysis of bacterial community dynamics in the lungs of cystic fibrosis patients
Melissa S. Doud, Department of Biological Sciences, Florida International University et al.
Review: Maternal transmission of Alzheimers disease: Prodromal metabolic phenotype and the search for genes
Lisa Mosconi, Center for Brain Health, Department of Psychiatry, New York University School of Medicine et al.
Genome Database: Review on CATH: Protein structure classification database
Michael Knudsen, Bioinformatics Research Centre and Carsten Wiuf, Centre for Membrane Pumps in Cells and Disease, Aarhus University
Update on gene completions and annotations: Human and mouse matrix metalloproteinase families
Brian C. Jackson, Molecular Toxicology and Environmental Health Sciences Program, Daniel W. Nebert, Department of Environmental Health and Center for Environmental Genetics and Vasilis Vasiliou, University of Colorado Denver
Software Review: An introduction to effective use of enrichment analysis software
Hannah Tipney and Lawrence Hunter, Center for Computational Pharmacology, University of Colorado Denver
Book Review: ‘Pharmaceutical Biotechnology – Concepts and Applications’ by Gary Walsh
Reviewed by Krishna Mallela, Department of Pharmaceutical Sciences, University of Colorado Denver
Meeting Report: Highlights of the Gene Nomenclature Across Species Meeting
Elspeth A. Bruford, Project Coordinator, HUGO Gene Nomenclature Committee
Guest Editorial: The Human Gene Mutation Database: Providing a comprehensive central mutation database for molecular diagnostics and personalised genomics
David N. Cooper, Human Molecular Genetics, Cardiff University School of Medicine; Curator, Human Gene Mutation Database et al.
Research: Detecting genes contributing to longevity using twin data
Alexander Begun, Institute of Medical Informatics and Statistics, Kiel University
Research: Identifying positive selection candidate loci for high-altitude adaptation in Andean populations
Abigail W. Bigham, Department of Anthropology, Pennsylvania State University
Review: Evolutionary dynamics of olfactory receptor genes in chordates: Interaction between environments and genomic contents
Yoshihito Niimura, Department of Bioinformatics, Medical Research Institute, Tokyo Medical and Dental University
Genome Database: The Aldehyde Dehydrogenase Gene Superfamily
Professor Vasilis Vasiliou, Director of the Toxicology Graduate Program, University of Colorado Health Sciences Center
Update on Gene Completions and Annotations: The mammalian aldehyde oxidase gene family
Enrico Garattini, Maddalena Fratelli and Mineko Terao, Laboratory of Molecular Biology, Department of Biochemistry and Molecular Pharmacology, Istituto di Ricerche Farmacologiche ‘Mario Negri’
Software Review: R and bioconductor solutions for alternative splicing detection
Tzu Lip Phang, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver
Book Review: ‘Neuroscience of Birdsong’ Edited by: H. Philip Zeigler and Peter Marler
Reviewed by Michael Stumpf, Imperial College London
Editorial
Vasilis Vasiliou, Director of the Toxicology Graduate Program, University of Colorado Health Sciences Center
Research: Genetic association tests: A method for the joint analysis of family and case-control data
Courtney Gray-McGuire, Department of Epidemiology and Biostatistics, Case Western Reserve University; Department of Arthritis and Immunology, Oklahoma Medical Research Foundation et al.
Review: Use of pathway information in molecular epidemiology
Duncan C. Thomas, Department of Preventive Medicine, University of Southern California et al.
Update on Gene Completions and Annotations: Evolutionary divergence and functions of the ADAM and ADAMTS gene families
Daniel W. Nebert, Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center et al.
Software Review: Genomics software – the view from 10,000 feet
Mike Weale, Centre for Genetic Anthropology, University College London
Genome Database: The Cytochrome P450 Homepage
David R. Nelson, Department of Molecular Sciences, University of Tennessee
Book Review: ‘Gene Sharing and Evolution' by Joram Piatigorsky
Reviewed by Ales Cvekl and Deyou Zheng, Albert Einstein College of Medicine